Association between elevated peripheral blood eosinophil count and respiratory outcomes in adults with cystic fibrosis

In cystic fibrosis (CF), chronic progressive lung disease is a key contributor to patient morbidity and is the leading cause of mortality [1]. There are a number of clinical factors that have been associated with lung function decline in CF, including female sex, airway microbiology (Pseudomonas aeruginosa, Burkholderia cepacia, MRSA), CF-related diabetes, and history of pulmonary exacerbations (PEx) [2]. In terms of biological markers, sputum neutrophil elastase predicts lung function decline and the development of bronchiectasis in CF, which suggests that neutrophil airway inflammation plays a central role in CF lung disease progression [3,4].

Source: Journal of Cystic Fibrosis - March 31, 2022 Category: Respiratory Medicine Authors: Si Cong Ye, Sameer Desai, Emma Karlsen, Eugenie Kwong, Pearce G. Wilcox, Bradley S. Quon Source Type: research