Lipid Lowering Effect of Ethanolic Extract of Aerial Parts of Peucedanum pastinacifolium Boiss. and Hausskn. in Hypercholesterolemic Rats
Increased plasma cholesterol is known to be a major risk related to the development of
coronary artery disease. The main purpose of this study was to determine possible effects
of the ethanolic extract of aerial parts of Peucedanum pastinacifolium on the serum lipids
in hypercholesterolemic rats. Experimental hypercholesterolemia was induced by feeding rats
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groups. One group did not receive treatments and served as a control hypercholesterolemic
group. The other four groups were fed the cholesterol-enriched diet in conjunction with
125, 250, 500 mg extract per kg of the body weight along with 20 mg atrovaststin per kg
body weight, in a daily oral dose. A normal group of rats fed with a plain chow diet was also
included in the study. After oral administration for 8 weeks, P. pastinacifolium extract produced
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levels and atherogenic indices in hypercholesterolemic groups (P< 0.05). P. pastinacifolium
extract had no effects on serum high-density lipoprotein cholesterol levels in these groups. It is
concluded that the extract of aerial parts of P. pastinacifolium exhibits lipid lowe...
Source: Iranian Journal of Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research