New Paradigms for Familiar Diseases: Lessons Learned on Circulatory Bacterial Signatures in Cardiometabolic Diseases
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1756-4509Despite the strongly accumulating evidence for microbial signatures in metabolic
tissues, including the blood, suggesting a novel paradigm for metabolic disease
development, the notion of a core blood bacterial signature in health and
disease remains a contentious concept. Recent studies clearly demonstrate that
under a strict contamination-free environment, methods such as 16 S rRNA
gene sequencing, fluorescence in-situ hybridization, transmission electron
microscopy, and several more, allied with advanced bioinformatics tools, allow
unambiguous detection and quantification of bacteria and bacterial DNA in human
tissues. Bacterial load and compositional changes in the blood have been
reported for numerous disease states, suggesting that bacteria and their
components may partially induce systemic inflammation in cardiometabolic
disease. This concept has been so far primarily based on measurements of
surrogate parameters. It is now highly desirable to translate the current
knowledge into diagnostic, prognostic, and therapeutic approaches.This review addresses the potential clinical relevance of a blood bacterial
signature pertinent to cardiometabolic diseases and outcomes and new avenues for
translational approaches. It discusses pitfalls related to research in low
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Source: Experimental and Clinical Endocrinology and Diabetes - Category: Endocrinology Authors: Chakaroun, Rima Massier, Lucas Musat, Niculina Kovacs, Peter Tags: Review Source Type: research
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