Characterization of Aripiprazole Uptake Transporter in the Blood-Brain Barrier Model hCMEC/D3 Cells by Targeted siRNA Screening

ConclusionsA knockdown screening study in combination withKp,uu,brain values showed that aripiprazole was a potential substrate of OCTN2. The technique described in this study can be applied to identifying novel BBB transporters for CNS drugs.

Source: Pharmaceutical Research - March 21, 2022 Category: Drugs & Pharmacology Source Type: research