DMBT1 is upregulated in cystic fibrosis, affects ciliary motility, and is reduced by acetylcysteine

ConclusionsDMBT1 is part of inflammatory processes in CF and may be used as a potential biomarker for CF lung disease and a potential tool to monitor CF progression. Furthermore, DMBT1 has a negative effect on ciliary motility thereby possibly compromising airway clearance. Application of ACC, leading to reduced DMBT1 concentrations, could be a potential therapeutic option for CF patients.
Source: Molecular and Cellular Pediatrics - Category: Cytology Source Type: research