Heterozygous Dnmt3a R878C Induces Expansion of Quiescent Hematopoietic Stem Cell Pool

Acute myeloid leukemia (AML) is a genetically heterogeneous disease characterized by clonal proliferation of myeloid progenitors and differentiation block. Clonal cytogenetic abnormalities are one of the most important prognostic factors in AML and are used to guide risk-adapted treatment strategies for patients. However, approximately 40% –50% of de novo adult AML patients have a normal karyotype and therefore lack informative cytogenetic markers (1). Recently, in cytogenetically-normal AML (CN-AML), acquired somatic mutations that can provide prognostic information were identified by comprehensive mutational analysis (23).

Source: Experimental Hematology - March 1, 2022 Category: Hematology Authors: Takashi Higo, Yutaro Suzuki, Michiaki Sato, Junji Koya, Hideaki Mizuno, Masashi Miyauchi, Yosuke Masamoto, Keisuke Kataoka, Yoshiki Sumitomo, Takako Tsuruta-Kishino, Tomohiko Sato, Mineo Kurokawa Tags: Article Source Type: research