Casein kinase 1 and disordered clock proteins form functionally equivalent, phospho-based circadian modules in fungi and mammals [Biochemistry]

Circadian clocks are timing systems that rhythmically adjust physiology and metabolism to the 24-h day–night cycle. Eukaryotic circadian clocks are based on transcriptional–translational feedback loops (TTFLs). Yet TTFL-core components such as Frequency (FRQ) in Neurospora and Periods (PERs) in animals are not conserved, leaving unclear how a 24-h period is...

http://www.pnas.org/content/119/9/e2118286119.short?rss=1

Source: Proceedings of the National Academy of Sciences - February 25, 2022 Category: Science Authors: Daniela Marzoll, Fidel E. Serrano, Anton Shostak, Carolin Schunke, Axel C. R. Diernfellner, Michael Brunner Tags: Biochemistry Biological Sciences Source Type: research