PRDM9 losses in vertebrates are coupled to those of paralogs ZCWPW1 and ZCWPW2 [Evolution]

In most mammals and likely throughout vertebrates, the gene PRDM9 specifies the locations of meiotic double strand breaks; in mice and humans at least, it also aids in their repair. For both roles, many of the molecular partners remain unknown. Here, we take a phylogenetic approach to identify genes that...

Source: Proceedings of the National Academy of Sciences - February 25, 2022 Category: Science Authors: Maria Izabel A. Cavassim, Zachary Baker, Carla Hoge, Mikkel H. Schierup, Molly Schumer, Molly Przeworski Tags: Evolution Biological Sciences Source Type: research