Nanobodies as allosteric modulators of Parkinson’s disease-associated LRRK2 [Biochemistry]

Mutations in the gene coding for leucine-rich repeat kinase 2 (LRRK2) are a leading cause of the inherited form of Parkinson’s disease (PD), while LRRK2 overactivation is also associated with the more common idiopathic form of PD. LRRK2 is a large multidomain protein, including a GTPase as well as a...

Source: Proceedings of the National Academy of Sciences - February 25, 2022 Category: Science Authors: Ranȷan K. Singh, Ahmed Soliman, Giambattista Guaitoli, Eliza Stormer, Felix von Zweydorf, Thomas Dal Maso, Asmaa Oun, Laura Van Rillaer, Sven H. Schmidt, Deep Chatterȷee, Joshua A. David, Els Pardon, Thomas U. Schwartz, Stefan Knapp, Eileen Tags: Biochemistry Biological Sciences Source Type: research