Obesity – A Matter of Motivation?
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1749-4852Excessive food intake and reduced physical activity have long been established as
primary causes of obesity. However, the underlying mechanisms causing this
unhealthy behavior characterized by heightened motivation for food but not for
physical effort are unclear. Despite the common unjustified stigmatization that
obesity is a result of laziness and lack of discipline, it is becoming
increasingly clear that high-fat diet feeding and obesity cause alterations in
brain circuits that are critical for the control of motivational behavior.In this mini-review, we provide a comprehensive overview of incentive motivation,
its neural encoding in the dopaminergic mesolimbic system as well as its
metabolic modulation with a focus on derangements of incentive motivation in
obesity. We further discuss the emerging field of metabolic interventions to
counteract motivational deficits and their potential clinical implications. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | open access Full text
Source: Experimental and Clinical Endocrinology and Diabetes - Category: Endocrinology Authors: Hanssen, Ruth Thanarajah, Sharmili E Tittgemeyer, Marc Br üning, Jens C. Tags: Mini-Review Source Type: research
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