Definition of a mouse microglial subset that regulates neuronal development and proinflammatory responses in the brain [Immunology and Inflammation]

Expression of Itgax (encoding the CD11c surface protein) and Spp1 (encoding osteopontin; OPN) has been associated with activated microglia that can develop in healthy brains and some neuroinflammatory disorders. However, whether CD11c and OPN expression is a consequence of microglial activation or represents a portion of the genetic program expressed...

Source: Proceedings of the National Academy of Sciences - February 17, 2022 Category: Science Authors: Xianli Shen, Yiguo Qiu, Andrew E. Wight, Hye-Jung Kim, Harvey Cantor Tags: Immunology and Inflammation Biological Sciences Source Type: research