The pathogenic R5L mutation disrupts formation of Tau complexes on the microtubule by altering local N-terminal structure [Biophysics and Computational Biology]

The microtubule-associated protein (MAP) Tau is an intrinsically disordered protein (IDP) primarily expressed in axons, where it functions to regulate microtubule dynamics, modulate motor protein motility, and participate in signaling cascades. Tau misregulation and point mutations are linked to neurodegenerative diseases, including progressive supranuclear palsy (PSP), Pick’s disease, and Alzheimer’s...

http://www.pnas.org/content/119/7/e2114215119.short?rss=1

Source: Proceedings of the National Academy of Sciences - February 8, 2022 Category: Science Authors: Alisa Cario, Adriana Savastano, Neil B. Wood, Zhu Liu, Michael J. Previs, Adam G. Hendricks, Markus Zweckstetter, Christopher L. Berger Tags: Biophysics and Computational Biology Biological Sciences Source Type: research