Chronic Morphine Induces IL-18 in Ileum Myenteric Plexus Neurons Through Mu-opioid Receptor Activation in Cholinergic and VIPergic Neurons

In conclusion, these data show that morphine increases IL-18 in ileum myenteric plexus neurons via activation of MORs in a subset of cholinergic and VIP neurons. Thus, understanding the neurochemistry and electrophysiology of MOR-expressing enteric neurons can help to delineate mechanisms by which morphine perturbs the gut barrier.Graphic Abstract

http://link.springer.com/10.1007/s11481-021-10050-3

Source: Journal of NeuroImmune Pharmacology - February 2, 2022 Category: Drugs & Pharmacology Source Type: research