Hyperthermia promotes exosome secretion by regulating Rab7b while increasing drug sensitivity in adriamycin-resistant breast cancer

CONCLUSIONS: Our results demonstrated a novel function of hyperthermia in promoting exosome secretion in adriamycin-resistant breast cancer cells and revealed the effects of hyperthermia on tumor cell biology. These hyperthermia-triggered exosomes can carry antitumor genes to the residual tumor and tumor microenvironment, which may be more beneficial to the effects of hyperthermia. These results represent an exploration of the relationship between therapeutic strategies and exosome biology.PMID:35100921 | DOI:10.1080/02656736.2022.2029585

Source: International Journal of Hyperthermia - February 1, 2022 Category: Internal Medicine Authors: Di Xu Wen-Juan Tang Yi-Zhi Zhu Zhen Liu Kai Yang Ming-Xing Liang Xiu Chen Yang Wu Jin-Hai Tang Wei Zhang Source Type: research