The essential role for endothelial cell sprouting in coronary collateral growth

Coronary collateral growth is a natural bypass for ischemic heart diseases. It offers tremendous therapeutic benefit, but the process of coronary collateral growth is incompletely understood due to limited preclinical murine models that would enable interrogation of its mechanisms and processes via genetic modification and lineage tracing. Understanding the processes by which coronary collaterals develop can unlock new therapeutic strategies for ischemic heart disease.
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Source Type: research