The essential role for endothelial cell sprouting in coronary collateral growth
Coronary collateral growth is a natural bypass for ischemic heart diseases. It offers tremendous therapeutic benefit, but the process of coronary collateral growth is incompletely understood due to limited preclinical murine models that would enable interrogation of its mechanisms and processes via genetic modification and lineage tracing. Understanding the processes by which coronary collaterals develop can unlock new therapeutic strategies for ischemic heart disease.
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Anurag Jamaiyar, Cody Juguilon, Weiguo Wan, Devan Richardson, Sofia Chinchilla, James Gadd, Molly Enrick, Tao Wang, Caige McCabe, Yang Wang, Chris Kolz, Alyssa Clark, Sathwika Thodeti, Vahagn Ohanyan, Feng Dong, Bin Zhou, William Chilian, Liya Yin Source Type: research