Pharmacokinetic ‐based failure of a detergent virucidal for SARS‐COV‐2 nasal infections: A preclinical study and randomized controlled trial

ConclusionsIn this randomized clinical trial of subjects with SARS-CoV-2 infection, a topical detergent-based virucidal agent had no effect on viral load or symptom scores. Complementary in vitro studies confirmed a lack of efficacy, reflective of pharmacokinetic failure and rapid absorption from nasal surfaces.This article is protected by copyright. All rights reserved

Source: International Forum of Allergy and Rhinology - January 18, 2022 Category: Allergy & Immunology Authors: Charles R. Esther, Kyle S. Kimura, Yu Mikami, Caitlin E. Edwards, Suman R. Das, Michael H. Freeman, Britton A. Strickland, Hunter M. Brown, Bronson C. Wessinger, Veerain C. Gupta, Kate Von Wahlde, Quanhu Sheng, Li Ching Huang, Daniel R. Bacon Tags: ORIGINAL ARTICLE Source Type: research