Nacre extract from pearl oyster attenuates amyloid beta-induced memory impairment

In this study, we investigated whether nacre extract improves memory impairment induced by intracerebroventricular injection of Aβ1–40. Administration of nacre extract led to recovery from Aβ1–40-induced impairments in object recognition, short-term memory, and spatial memory. Nacre extract reversed the increase in lipid peroxidation caused by Aβ1–40 in the cerebral cortex by increasing the expression of catalase and superoxide dismutase. In addition, nacre extract recovered the expression and phosphorylation o f cyclic AMP response element-binding protein (CREB), which decreased with Aβ1–40 treatment, and increased the expression of brain-derived neurotrophic factor and neuropeptide Y, which are regulated by CREB. Nacre extract also suppressed acetylcholine esterase activity and Aβ1–40-induced tau p hosphorylation. Histochemical analysis of the hippocampus region showed that the nacre extract protected against Aβ1–40-induced neuronal loss in the hippocampus. These results suggest that nacre extract protects against Aβ1–40-induced neuronal cell death by suppressing oxidative stress and inc reasing the expression and phosphorylation of CREB.Graphical abstract
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research