Elevated International Normalized Ratio is correlated with large volume transfusion in pediatric trauma patients

Trauma is the leading cause of death in children, with most fatalities caused by brain injury or hemorrhage [1,2]. The presence of ongoing bleeding can lead to metabolic acidosis and coagulopathy, which is associated with increased morbidity and mortality [2-6]. Children who require a transfusion within the first 24 hours of presentation to the emergency department are more likely to have coagulopathy and abnormal serum lactate [7]. Similarly, abnormal base deficit is an independent predictor of transfusion requirements and mortality among pediatric trauma patients [8].

Source: Journal of Pediatric Surgery - January 13, 2022 Category: Surgery Authors: Danielle Mackenzie, Daniel Briatico, Michael H Livingston, Tony Beshay, Tessa Robinson, Forough Farrokhyar, Karen Bailey Source Type: research