Lack of collagen VIII reduces fibrosis and promotes early mortality and cardiac dilatation in pressure overload in mice

Conclusion
Lack of colVIII reduces myofibroblast differentiation and fibrosis and promotes early mortality and LV dilatation in response to pressure overload in mice.

Source: Cardiovascular Research - March 17, 2015 Category: Cardiology Authors: Skrbic, B., Engebretsen, K. V. T., Strand, M. E., Lunde, I. G., Herum, K. M., Marstein, H. S., Sjaastad, I., Lunde, P. K., Carlson, C. R., Christensen, G., Bjornstad, J. L., Tonnessen, T. Tags: Cardiac biology and remodelling Source Type: research