Inorganic polyphosphate elicits proinflammatory responses through activation of mTOR complexes 1 and 2 in vascular endothelial cells

ConclusionsPolyP, through interaction with RAGE and P2Y1, activates both mTORC1 and mTORC2 signaling network. Both proinflammatory and mTOR signaling functions of polyP are linked.This article is protected by copyright. All rights reserved.

Source: Journal of Thrombosis and Haemostasis - March 16, 2015 Category: Hematology Authors: Seyed Mahdi Hassanian, Peyman Dinarvand, Stephanie A. Smith, Alireza R. Rezaie Tags: Original Article ‐ Vascular Biology Source Type: research