Siponimod Inhibits the Formation of Meningeal Ectopic Lymphoid Tissue in Experimental Autoimmune Encephalomyelitis

Discussion Beneficial effects on the disease course correlated with a reduction in mELT, suggesting that inhibition of mELT may be an additional mechanism of action of siponimod in the treatment of EAE. Further studies are needed to establish causality and confirm this observation in MS.

http://nn.neurology.org/cgi/content/short/9/1/e1117?rss=1

Source: Neurology Neuroimmunology and Neuroinflammation - December 15, 2021 Category: Neurology Authors: Brand, R. M., Diddens, J., Friedrich, V., Pfaller, M., Radbruch, H., Hemmer, B., Steiger, K., Lehmann-Horn, K. Tags: Multiple sclerosis Article Source Type: research