RAS-Driven Macropinocytosis of Albumin or Dextran Reveals Mutation-Specific Target Engagement of RAS p.G12C Inhibitor ARS-1620 by NIR-Fluorescence Imaging

ConclusionsThese data provide a novel approach using NIR-labeled human serum albumin to identify and monitor RAS-driven tumors as well as evaluate the on-target efficacyin vivo of inhibitors, such as ARS-1620.
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research