Clinical Diagnostic Accuracy of Early/Advanced Parkinson Disease: An Updated Clinicopathologic Study

Conclusions
This updated study confirmed lower clinical diagnostic accuracy for elderly, untreated or poorly responsive PossPD participants and for ProbPD with <5 years of disease duration, even when medication responsive. Caution continues to be needed when interpreting clinical studies of PD, especially studies of early disease, that do not have autopsy confirmation.

Classification of Evidence
This study provides Class II evidence that a clinical diagnosis of ProbPD at the first visit identifies participants who will have pathologically confirmed PD with a sensitivity of 82.6% and a specificity of 86.0%.

Source: Neurology Clinical Practice - August 9, 2021 Category: Neurology Authors: Adler, C. H., Beach, T. G., Zhang, N., Shill, H. A., Driver-Dunckley, E., Mehta, S. H., Atri, A., Caviness, J. N., Serrano, G., Shprecher, D. R., Sue, L. I., Belden, C. M. Tags: Parkinson's disease/Parkinsonism, Progressive supranuclear palsy Research Source Type: research