Multidrug-resistant < em > Acinetobacter baumannii < /em > infections: looming threat in the Indian clinical setting

Expert Rev Anti Infect Ther. 2021 Dec 8. doi: 10.1080/14787210.2022.2016393. Online ahead of print.ABSTRACTINTRODUCTION: The recent increase in multidrug-resistant strains of A. baumannii has increased the incidences of ventilator-associated pneumoniae, catheter-associated urinary tract infections and central line- associated blood stream infections, together increasing hospital stay, treatment cost and mortality. Resistance genes blaOXA and blaNDM are dominant in India. Carbapenem-resistant A. baumannii (CRAB) International clone-2 (IC-2) are rising in India. High dependency on carbapenems and last-resort combination of tigecycline and polymyxins have aggravated outcomes. Despite nursing barriers, ward closure, environmental disinfections etc for detecting and controlling transmission, MDR isolates and CRAB nosocomial outbreaks continue. Treatment cost overruns by AMR adversely affect 80% of Indians without insurance cover.AREA COVERED: This narrative review will cover epidemiology, resistance pattern, genetic diversity, device-related infection, cost and mortality due to multidrug-resistant and CRAB in India. A comprehensive literature search in PUBMED and Google Scholar using appropriate keywords at different time points yielded relevant articles.EXPERT OPINION: It is challenging to enforce policies to control MDR A. baumannii in India. Government and hospitals should enforce stringent infection control measures, surveillance, and antimicrobial stewardship to prevent furth...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Authors: Source Type: research