AMRA Medical gets FDA clearance for MasS Scan

Swedish image analysis software developer AMRA Medical has received U.S. Foo...Read more on AuntMinnie.comRelated Reading: Canada greenlights distribution of AMRA's muscle scan AMRA touts liver MRI research at AASLD show AMRA joins clinical trial on muscular dystrophy AMRA touts clinical trial results AMRA adds UK Biobank images to database
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news

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Swedish image analysis software developer AMRA Medical has received licensin...Read more on AuntMinnie.comRelated Reading: AMRA touts liver MRI research at AASLD show AMRA joins clinical trial on muscular dystrophy AMRA touts clinical trial results AMRA adds UK Biobank images to database AMRA teams up with National University of Singapore
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
A proportion of patients with Duchenne muscular dystrophy (DMD) have behavioural and cognitive deficits. Magnetic resonance imaging (MRI) has demonstrated reduced grey matter volume, altered white matter structural integrity and reduced perfusion compared to age-matched controls. Here we report the first results of a longitudinal study of brain structure in adolescents with DMD compared controls. 28 DMD and 20 control participants were scanned, with a 2- to 4-year time-window. 3D T1-weighted scans were acquired at 3 Tesla.
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research
Prednisolone and deflazacort have been proven to be effective in slowing down Duchenne muscular dystrophy (DMD) disease progression. Previous studies in other pathologies demonstrated corticosteroids can cross the blood-brain barrier and cause brain atrophy. In this pilot study, we assessed the effect of both compounds on brain structure in boys with DMD. 3D T1-weighted images were obtained on a 3T Philips system at two different sites. Scans from 20 DMD patients (n=10 daily deflazacort (13.1 ±3.1y), n=10 10 days on/10 days off prednisolone (13.0±3.0y)) and 16 age-matched healthy controls (14.0±2.8y) w...
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research
Quantitative MRI (qMRI) of skeletal muscles is a promising method to objectively assess muscle involvement in Duchenne muscular dystrophy (DMD) and a potential outcome measure in clinical trials. qMRI data of the upper extremity (UE) muscles in non-ambulant DMD patients are limited. Therefore, we longitudinally assessed qMRI and UE functional outcome measures in this stage of the disease. 4-point Dixon MRI scans (3T) of the right upper arm, performance of the upper limb (PUL) version 2.0 and elbow flexion and grip strength were measured at baseline, 12 and 18 months follow-up.
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research
ConclusionsWe identified MRI patterns that showed a high diagnostic power in promptly discriminating FSHD from other muscle disorders, with comparable performance irrespective of typical or atypical clinical features. Upper girdle in addition to lower-limb muscle imaging should be extensively implemented in the diagnostic workup to support or exclude a diagnosis of FSHD.
Source: Journal of Neurology - Category: Neurology Source Type: research
Am J Physiol Cell Physiol. 2021 Aug 25. doi: 10.1152/ajpcell.00122.2021. Online ahead of print.ABSTRACTDuchenne muscular dystrophy (DMD) is the second most common fatal genetic disease in humans and is characterized by the absence of a functional copy of the protein dystrophin from skeletal muscle. In dystrophin-negative humans and rodents, regenerated skeletal muscle fibers show abnormal branching. The number of fibers with branches and the complexity of branching increases with each cycle of degeneration/regeneration. Previously, using the mdx mouse model of DMD, we have proposed that once the number and complexity of br...
Source: American Journal of Physiology. Cell Physiology - Category: Cytology Authors: Source Type: research
As putative treatments are developed for Duchenne muscular dystrophy (DMD), sensitive, non-invasive measures are increasingly important to quantify disease progression. Fibrosis is one of the histological hallmarks of muscular dystrophy and has been directly linked to prognosis. EP3533 is a novel contrast agent with an affinity to collagen 1 that has demonstrated a significant and high correlation to ex vivo fibrosis quantification. Halofuginone is an established anti-fibrotic compound shown to reduce collagen skeletal muscle fibrosis in murine models of DMD. This experiment explored whether EP3533 could be used to detect ...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Introduction: Paraspinal muscles are important for gross motor functions. Impairment of these muscles can lead to poor postural control and ambulation difficulty. Little knowledge exists about the involvement of paraspinal muscles in Becker muscular dystrophy.Objective: In this cross-sectional study, we investigated the involvement of paraspinal muscles with quantitative trunk strength measure and quantitative muscle MRI.Methods and Materials: Eighteen patients with Becker muscular dystrophy underwent trunk, hip, and thigh strength assessment using a Biodex dynamometer and an MRI Dixon scan. Fourteen age- and body mass ind...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Mol Med Rep. 2021 Jun;23(6):480. doi: 10.3892/mmr.2021.12119. Epub 2021 Apr 26.ABSTRACTLimb-girdle muscular dystrophy recessive 1 (LGMDR1), a rare subtype of muscular dystrophy, is characterized by progressive muscle weakness and degeneration with a predominant presentation on the shoulder, pelvic and proximal limb muscles. Variants in calcium-activated neutral proteinase 3 (CAPN3), which encodes an enzyme, calpain 3, are considered the major cause of LGMDR1. The present study was conducted to identify the variants responsible for clinical symptoms in a Chinese patient with limb-girdle muscular dystrophies (LGMDs) and expl...
Source: Molecular Medicine Reports - Category: Molecular Biology Authors: Source Type: research
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