miR-1270 enhances the proliferation, migration, and invasion of osteosarcoma < em > via < /em > targeting cingulin

In this study, miR-1270 was overexpressed in OS tissues and cells. However, miR-1270 knockdown inhibited the proliferation, migration and invasion, and promoted the OS cells ’ apoptosis. Mechanistically, cingulin (CGN) was predicted and proved to be a target of miR-1270 and partially alleviated the effects of miR-1270 on the proliferation, migration and invasion ability of OS cells. Taken together, knockdown of miR-1270 may inhibit the development of OSvia targeting CGN. This finding may provide a novel therapeutic strategy for OS.
Source: European Journal of Histochemistry - Category: Biomedical Science Authors: Source Type: research