Traditional Uses, Pharmacological Effects, and Molecular Mechanisms of Licorice in Potential Therapy of COVID-19

The current Coronavirus disease 2019 (COVID-19) pandemic has become a global challenge, and although vaccines have been developed, it is expected that mild to moderate patients will control their symptoms, especially in developing countries. Licorice, not only a food additive, but also a common traditional Chinese herbal medicine, which has several pharmacological effects, such as anti-inflammation, detoxification, antibacterial, antitussive, and immunomodulatory effects, especially in respiratory diseases. Since the outbreak of COVID-19, glycyrrhizin, glycyrrhizin diamine and glycyrrhizin extract have been widely studied and used in COVID-19 clinical trials. Therefore, it is a very interesting topic to explore the material basis, pharmacological characteristics and molecular mechanism of licorice in adjuvant treatment of COVID-19. In this paper, the material basis of licorice for the prevention and treatment of COVID-19 is deeply analyzed, and there are significant differences among different components in different pharmacological mechanisms. Glycyrrhizin and glycyrrhetinic acid inhibit the synthesis of inflammatory factors and inflammatory mediators by blocking the binding of ACE 2 to virus spike protein, and exert antiviral and antibacterial effects. Immune cells are stimulated by multiple targets and pathways to interfere with the pathogenesis of COVID-19. Liquiritin can prevent and cure COVID-19 by simulating type I interferon. It is suggested that licorice can exert it...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

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(BEIJING, China) — A cluster of COVID-19 cases in Beijing has prompted authorities to test millions and impose new measures two weeks ahead of the opening of the Winter Olympics, even as the city of Xi’an in north-central China lifted on Monday a monthlong lockdown that had isolated its 13 million residents. Officials in Beijing said they would conduct a second round of mass testing of the Fengtai district’s 2 million residents, where the majority of the capital’s 40 coronavirus cases since Jan. 15 have been found. That came a day after authorities announced that anyone who buys or who has bought fe...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 healthscienceclimate News Desk wire Source Type: news
In conclusion, the survey provided information about the German population’s perception and knowledge of the coronavirus five months into the pandemic; however, participants were younger and more educated than a representative sample. To learn from the beginning and still ongoing pandemic and develop concepts for the future, we need more conclusive studies, especially on the acceptance of further specified lockdowns, the population’s willingness to be vaccinated, and the influence of misinformation on public opinion.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Homœopathic Links 2021; 34: 112-118 DOI: 10.1055/s-0041-1732782Coronavirus disease 2019 (COVID-19) is a zoonotic disease caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). Its symptoms range from mild fever, cough, pharyngitis to severe acute respiratory syndrome. Since its first outbreak in Wuhan province of China, the disease has spread worldwide and emerged as pandemic. The infection is mainly spread by droplets and through contacts. Initially SARS-CoV-2 was thought to cause viral pneumonia only, but now it is evident that the virus can spread through the bloodstream and can cause systemi...
Source: Homoeopathic Links - Category: Complementary Medicine Authors: Tags: Review Article Source Type: research
Everest South Base Camp lies at an altitude of 17,598 feet (5,364 m), but it is no refuge from the global pandemic. The Nepali Sherpas who, in normal times, share the camaraderie of climbers on the world’s highest mountain, now enforce strict social-distancing rules, remaining within their separate camps—indeed, mostly inside their own tents. “We have made a rule not to walk from one camp to another as some climbers have tested positive,” says Phunuru, a Sherpa guide. “If we see somebody new walking around our camp, we immediately start an inquiry.” Officially, there is no coronavirus he...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 Nepal overnight Source Type: news
Curr Microbiol. 2021 Feb 27. doi: 10.1007/s00284-021-02396-x. Online ahead of print.ABSTRACTA novel coronavirus member was reported in Wuhan City, Hubei Province, China, at the end of the year 2019. Initially, the infection spread locally, affecting the Wuhan people, and then expanded rapidly throughout the world. On 11 March 2020, the World Health Organization (WHO) proclaimed it a global pandemic. The virus is a new strain most closely related to a bat coronavirus (RaTG13) which was not previously discovered in humans and is now formally known as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Coronavir...
Source: Current Microbiology - Category: Microbiology Authors: Source Type: research
Approaches towards fighting the COVID‑19 pandemic (Review). Int J Mol Med. 2020 Nov 20;: Authors: Tsai SC, Lu CC, Bau DT, Chiu YJ, Yen YT, Hsu YM, Fu CW, Kuo SC, Lo YS, Chiu HY, Juan YN, Tsai FJ, Yang JS Abstract The coronavirus disease 2019 (COVID‑19) outbreak, which has caused>46 millions confirmed infections and>1.2 million coronavirus related deaths, is one of the most devastating worldwide crises in recent years. Infection with COVID‑19 results in a fever, dry cough, general fatigue, respiratory symptoms, diarrhoea and a sore throat, similar to those of acute respiratory dis...
Source: International Journal of Molecular Medicine - Category: Molecular Biology Authors: Tags: Int J Mol Med Source Type: research
Coronavirus has shattered our world and changed nearly all aspects of our lives. It has also changed our relationship to healthcare. It is slowly becoming a cliché to say that COVID-19 has catalysed healthcare trends – but nevertheless, it’s true. Everyone in the world has seen what devastating impact healthcare can have on our daily lives and how underfunded healthcare systems depend on the heroic frontline workers, who are holding the walls from falling apart. The windfall of the era of digital health is unquestionable, but it has always been. The hurdle was the adoption of these changes, for they p...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Forecast Lifestyle medicine Artificial Intelligence in Medicine Digital Health Research E-Patients Future of Medicine Future of Pharma Healthcare Design Healthcare Policy Medical Education AI MIT covid19 Source Type: blogs
Abstract Since the discovery of the yellow fever virus in 1901, thus far, two hundred nineteen viral species are recognized as human pathogens. Each year, the number of viruses causing infections in humans increases, triggering epidemics and pandemics, such as the current COVID-19 pandemic. Pointing to bats as the natural host, in 2019, a genome highly identical to a bat coronavirus (COVID-19) spread all over the world, and the World Health Organization (WHO) officially confirmed it as a pandemic. The virus mainly spreads through the respiratory tract, uses angiotensin-converting enzyme 2 (ACE2) as a receptor, and...
Source: European Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Eur J Pharmacol Source Type: research
Suppose you are suddenly are stricken with COVID-19. You become very ill for several weeks. On awakening every morning, you wonder if this day might be your last. And then you begin to turn the corner. Every day your worst symptoms — the fever, the terrible cough, the breathlessness — get a little better. You are winning, beating a life-threatening disease, and you no longer wonder if each day might be your last. In another week or two, you’ll be your old self. But weeks pass, and while the worst symptoms are gone, you’re not your old self — not even close. You can’t meet your responsibi...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Brain and cognitive health Coronavirus and COVID-19 Fatigue Source Type: blogs
The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 infection has recently spread worldwide was declared a pandemic on March 11. The most common symptoms of COVID-19 disease are fever, fatigue, and dry cough. Some patients may experience pain and aches, nasal congestion, cold, sore throat or diarrhea. These symptoms are usually mild and begin gradually. Currently, the source of the virus is still unknown. However, all available evidence indicates that the origin of this virus is a natural animal and that it is not a manufactured virus. The virus spreads faster than ...
Source: Reviews in Medical Microbiology - Category: Microbiology Tags: VIROLOGY Source Type: research
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