Sphenocentrum jollyanum root and leaf extracts enhanced wound closure by improving the glycemic state of diabetic rats induced by high-fat diet/streptozotocin

This study evaluates the effect ofSphenocentrum jollyanum root and leaf extracts on glycemic state and wound closure in a type 2 diabetic rat induced by high fat diet and streptozotocin (STZ). The experimental animals were fed high fat diet for 14  days, and low dose (35 mg/kg) of streptozotocin (STZ) was afterwards administered intraperitoneally. The blood glucose of the animals were measured after 72 h of STZ administration and wound subsequently created. The rats were givenS. jollyanum extracts (100 and 200  mg/kg b.w) through oral gavage and also administered topically on the wound area for two weeks. An increased level of glucose, glycated hemoglobin, and lipids, as well as activities of α-amylase, α-glucosidase, and lipase observed in diabetic rats was reduced significantly (P <  0.05) after treatment withS. jollyanum extracts. Furthermore, wound contraction rate was faster with administration of the root extract in comparison to the diabetic control. Maintaining a steady glycemic state is essential in diabetic wound repair, and the findings from this research suggest thatS. jollyanum may represent a source of phytochemicals for the treatment of diabetic wound.
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research