The central executive network and executive function in healthy and persons with schizophrenia groups: a meta-analysis of structural and functional MRI

AbstractThis meta-analysis evaluated the extent to which executive function can be understood with structural and functional magnetic resonance imaging. Studies included structural in schizophrenia (k = 8;n = 241) and healthy controls (k = 12;n = 1660), and functional in schizophrenia (k = 4; n = 104) and healthy controls (k = 12;n = 712). Results revealed a positive association in the brain behavior relationship when pooled across schizophrenia and control samples for structural (pr = 0.27) and functional (pr = 0.29) modalities. Subgroup analyses revealed no significant difference for functional neuroimaging (pr = .43, 95%CI = -.08-.77,p = .088) but with structural neuroimaging (pr = .37, 95%CI = -.08-.69,p = .015) the association to executive functions is lower in the control group. Subgroup analyses also revealed no significant differences in the strength of the brain-behavior relationship in the schizophrenia group (pr = .59, 95%CI = .58-.61,p = .881) or the control group (pr = 0.19, 95%CI = 0.18–0.19,p = 0.920), suggesting concordance.
Source: Brain Imaging and Behavior - Category: Neurology Source Type: research