Diagnostic utility of transbronchial biopsy for Hodgkin's lymphoma: A case study
Here, we report a case of undiagnosed HL with lung lesions despite multiple TBBs. Our literature review indicated that the diagnostic success rate of TBB was low (18.5%) in cases of lung lesions in HL. Surgical biopsy should be considered early to avoid a delay in diagnosis because the diagnostic ability of TBB for HL patients with lung lesions is limited. AbstractLung lesions of Hodgkin's lymphoma (HL) are rare and difficult to diagnose by nonsurgical biopsy. We herein present the case of a 72-year-old Japanese male who presented with accumulation of lung infiltrates and masses bilaterally on the lungs for 3  years. Although transbronchial lung biopsy (TBB) and computed tomography-guided biopsy were conducted several times, his diagnosis remained inconclusive. On further deterioration of lung lesions, the patient was transferred to our hospital. Positron emission tomography revealed increased accumula tion in the bilateral lungs and right supraclavicular lymph nodes. Surgical biopsy of the lymph node was performed. He was finally diagnosed with HL and underwent chemotherapy with doxorubicin, vinblastine, dacarbazine, and brentuximab vedotin. After chemotherapy, the lung lesion showed significant regression. A literature review indicated that the diagnostic success rate of TBB was low (18.5%) in cases of lung lesions in HL.
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Miki Hoshi,
Nobuaki Kobayashi,
Katsushi Tanaka,
Kohei Somekawa,
Ayami Kaneko,
Ami Izawa,
Kenichi Seki,
Yoichi Tagami,
Ayako Aoki,
Hiroaki Fujii,
Keisuke Watanabe,
Nobuyuki Horita,
Yu Hara,
Mai Matsumura,
Makiko Enaka,
Maki Hagihara,
Takesh Tags: CASE REPORT Source Type: research
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