Simultaneous Use of Hypertonic Saline and IV Furosemide for Fluid Overload: A Systematic Review and Meta-Analysis
OBJECTIVES:
To evaluate the efficacy of the simultaneous hypertonic saline solution and IV furosemide (HSS+Fx) for patients with fluid overload compared with IV furosemide alone (Fx).
DATA SOURCES:
Electronic databases (MEDLINE, EMBASE, CENTRAL, Cochrane Database of Systematic Reviews, PsycINFO, Scopus, and WOS) were searched from inception to March 2020.
STUDY SELECTION:
Randomized controlled trials on the use of HSS+Fx in adult patients with fluid overload versus Fx were included.
DATA EXTRACTION:
Data were collected on all-cause mortality, hospital length of stay, heart failure–related readmission, along with inpatient weight loss, change of daily diuresis, serum creatinine, and 24-hour urine sodium excretion from prior to post intervention. Pooled analysis with random effects models yielded relative risk or mean difference with 95% CIs.
DATA SYNTHESIS:
Eleven randomized controlled trials comprising 2,987 acute decompensated heart failure patients were included. Meta-analysis demonstrated that HSS+Fx was associated with lower all-cause mortality (relative risk, 0.55; 95% CI, 0.46–0.67; p
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Online Review Article Source Type: research
More News: Cardiology | Databases & Libraries | Emergency Medicine | Furosemide | Heart | Heart Failure | Hospitals | Sodium | Study | Weight Loss