Cancers, Vol. 13, Pages 5301: Identification of MicroRNA –mRNA Networks in Melanoma and Their Association with PD-1 Checkpoint Blockade Outcomes
Cancers, Vol. 13, Pages 5301: Identification of MicroRNA–mRNA Networks in Melanoma and Their Association with PD-1 Checkpoint Blockade Outcomes
Cancers doi: 10.3390/cancers13215301
Authors:
Robert A. Szczepaniak Sloane
Michael G. White
Russell G. Witt
Anik Banerjee
Michael A. Davies
Guangchun Han
Elizabeth Burton
Nadim Ajami
Julie M. Simon
Chantale Bernatchez
Lauren E. Haydu
Hussein A. Tawbi
Jeffrey E. Gershenwald
Emily Keung
Merrick Ross
Jennifer McQuade
Rodabe N. Amaria
Khalida Wani
Alexander J. Lazar
Scott E. Woodman
Linghua Wang
Miles C. Andrews
Jennifer A. Wargo
Metastatic melanoma is a deadly malignancy with poor outcomes historically. Immuno-oncology (IO) agents, targeting immune checkpoint molecules such as cytotoxic T-lymphocyte associated protein-4 (CTLA-4) and programmed cell death-1 (PD-1), have revolutionized melanoma treatment and outcomes, achieving significant response rates and remarkable long-term survival. Despite these vast improvements, roughly half of melanoma patients do not achieve long-term clinical benefit from IO therapies and there is an urgent need to understand and mitigate mechanisms of resistance. MicroRNAs are key post-transcriptional regulators of gene expression that regulate many aspects of cancer biology, including immune evasion. We used network analysis to define two core microRNA–mRNA networks in melanoma tissues and cell lines corresponding to ‘MITF-low’ and ‘Keratin’ tran...
Source: Cancers - Category: Cancer & Oncology Authors: Robert A. Szczepaniak Sloane Michael G. White Russell G. Witt Anik Banerjee Michael A. Davies Guangchun Han Elizabeth Burton Nadim Ajami Julie M. Simon Chantale Bernatchez Lauren E. Haydu Hussein A. Tawbi Jeffrey E. Gershenwald Emily Keung Merrick Ross Je Tags: Article Source Type: research