Primary Bedaquiline Resistance Among Cases of Drug-Resistant Tuberculosis in Taiwan

Bedaquiline (BDQ), which is recommended for the treatment of drug-resistant tuberculosis (DR-TB), was introduced in Taiwan in 2014. Due to the alarming emergence of BDQ resistance, we conducted BDQ resistance analyses to strengthen our DR-TB management program. This retrospective population-based study included initial Mycobacterium tuberculosis isolates from 898 rifampicin-resistant (RR) or multidrug-resistant (MDR) TB cases never exposed to BDQ during 2008–2019. We randomly selected 65 isolates and identified 28 isolates with BDQ MIC
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research

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ConclusionsThis qualitative analysis highlights ways in which insights developed together with patients and healthcare workers might inform approaches towards improved recruitment into trials, with the overall objective of delivering evidence for better treatments.
Source: Trials - Category: Research Source Type: clinical trials
There was a complete lack of information about the treatment outcomes of rifampicin/multidrug resistant (RR/MDR) childhood TB patients (age  ≤ 14 years) from Pakistan, an MDR-TB 5th high burden country. Therefo...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Research Source Type: research
Antimicrob Agents Chemother. 2021 Nov 29:AAC0160821. doi: 10.1128/AAC.01608-21. Online ahead of print.ABSTRACTA population pharmacokinetic analysis of delamanid and its major metabolite DM-6705 was conducted to characterize the pharmacokinetics of delamanid and DM-6705 in pediatric participants with multidrug-resistant tuberculosis (MDR-TB). Data from participants between the ages of 0.67 to 17 years old, enrolled in 2 clinical trials, were utilized for the analysis. The final dataset contained 634 delamanid and 706 DM-6705 valid plasma concentrations from 37 children. A transit model with three compartments best described...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Source Type: research
Appl Microbiol Biotechnol. 2021 Nov 29. doi: 10.1007/s00253-021-11690-4. Online ahead of print.ABSTRACTChitosan (CS) is a promising biopolymer and has been tested as a complement to the action and compensation of toxicity presented by anti-tuberculosis drugs. The present work studied the adjuvant effect of CS with the drug ethambutol (EMB) as a compound (CS-EMB), to explore its antimicrobial and cytotoxic activity, using transmission electron microscopy (TEM), to examine ultracellular changes that represent possible antimycobacterial action of CS on Mycobacterium tuberculosis (Mtb). Antimycobacterial activities were tested...
Source: Applied Microbiology and Biotechnology - Category: Microbiology Authors: Source Type: research
Conclusion: TB fight can be successful with TB control programs that are carried out with determination.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis and non-tuberculous mycobacterial diseases Source Type: research
Conclusion: NTM in respiratory samplings doesn’t mean infection. PTB infection seems to be the major risk factor. M. avium complex was the most prevalent species in our study.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis and non-tuberculous mycobacterial diseases Source Type: research
Background: In Malaysia, multidrug-resistant tuberculosis (MDR-TB) is currently a significant public health concern.Objective: This research aims to determine the prevalence of MDR-TB in patients with tuberculosis in Malaysia.Method: A retrospective review was conducted, and data was collected from the Malaysian National TB Information System (TBIS) between 2009 and 2019. A total of 989 cases of MDR-TB have been reported and associated risk characteristics have been determined, such as marital status, gender, ethnicity, employment status, consumption of alcohol, diabetic status and smoking status. The statistical analysis ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Epidemiology Source Type: research
Conclusions: BAL improves the effectiveness of MBT detection in children and adolescents with pulmonary TB without MTB positive sputum samples by 60 % (95%CI: 43.6 -74.5) Wilson's method) due to RMT. Depending on the age, the effectiveness ranges from 33.3% to 80%.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis and non-tuberculous mycobacterial diseases Source Type: research
Therapeutic drug monitoring (TDM) has been suggested to improve treatment responses in multidrug- and extensively drug-resistant tuberculosis (M/XDR-TB), but evidence is still scarce. We share our experience with TDM in anti-tuberculosis therapy in a patient with very advanced XDR-TB.A 34-year-old male from Ukraine was admitted to our hospital in November 2018 for the treatment of tuberculosis. He had been diagnosed in December 2008 and had since received 8 treatment episodes in Ukraine with relapses and failing therapies. On admission, time to positivity for Mycobacterium tuberculosis in liquid sputum culture was 7 days. ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis and non-tuberculous mycobacterial diseases Source Type: research
The objectives of a WHO convened online expert consultation meeting held in October 2020 were to determine how recent changes in treatment regimens and diagnostics for drug-resistant TB might affect the definition of XDR-TB and discuss options for changing it.Methods: The latest WHO policy recommendations on treatment regimens and diagnostics for drug resistant TB were presented as well as independent research.Results: The WHO has proposed a definition of pre-XDR-TB as well as a revised definition of XDR-TB, which apply from January 2021 (Table 1) (WHO, 2021). Table 1:The new definition of pre-XDR-TB and the revised defini...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis and non-tuberculous mycobacterial diseases Source Type: research
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