Sex ‐specific Neurotoxicity of Dietary Advanced Glycation end Products in APP/PS1 Mice and Protective Roles of Trehalose by Inhibiting Tau Phosphorylation Via GSK‐3β‐TFEB

Conclusions: Female mice were more susceptible to the deleterious effects of dAGEs on cognitive function, which might be owing to its regulation on ER β. Trehalose could strongly reverse dAGEs-induced tau phosphorylation by potentiating TFEB nuclear translocation via inhibiting GSK-3β.This article is protected by copyright. All rights reserved

Source: Molecular Nutrition and Food Research - October 20, 2021 Category: Food Science Authors: Huan ‐Huan Zhou, Lan Luo, Xue‐Di Zhai, Liangkai Chen, Guiping Wang, Li‐Qiang Qin, Zengli Yu, Li‐Li Xin, Zhongxiao Wan Tags: Research Article Source Type: research