Evaluation of Age-Dependent Immune Signatures in Patients With Multiple Sclerosis

Discussion
Our data illustrate that aging in MS is associated with a dysbalance between costimulatory and immunoregulatory signals provided by CD8 T cells favoring a proinflammatory phenotype and, more importantly, a pattern of premature immune aging in the CD8 T-cell compartment of young patients with MS with potential implications for disease severity.

Source: Neurology Neuroimmunology and Neuroinflammation - October 19, 2021 Category: Neurology Authors: Eschborn, M., Pawlitzki, M., Wirth, T., Nelke, C., Pfeuffer, S., Schulte-Mecklenbeck, A., Lohmann, L., Rolfes, L., Pape, K., Eveslage, M., Bittner, S., Gross, C. C., Ruck, T., Wiendl, H., Meuth, S. G., Klotz, L. Tags: Autoimmune diseases, Multiple sclerosis Article Source Type: research