Gastroparesis

Purpose of review This review highlights recent research advances regarding the pathophysiology and treatment of gastroparesis. Recent findings Differences in brain activity have been identified on functional MRI imaging in gastroparesis patients with nausea. Abdominal pain is common in patients with gastroparesis and does not correlate with the severity of gastric emptying delay, though may be associated with depression and anxiety. Autonomic dysfunction may play an important role in the pathophysiology of gastroparesis. There is increasing sentiment that gastroparesis should be considered a part of the same spectrum of gastric neuromuscular disorders. The risk of tardive dyskinesia with metoclopramide has likely been significantly overestimated historically. Endoscopic BoTox injection of the pylorus and gastric electrical stimulation remain controversial treatments for gastroparesis. New, highly selective 5-hydroxytryptamine 4 (5-HT4) agonists appear safe and may be effective in improving symptoms of gastric emptying. Long-term data assessing the use of gastric peroral endoscopic myotomy (G-POEM) for the treatment of refractory gastroparesis suggest durable clinical improvement. Summary Altered central processing and autonomic dysfunction may be important factors in the pathogenesis of gastroparesis. While the risk of tardive dyskinesia appears much lower than historically advertised, there is increasing hope for novel therapeutics with the advent of new 5...
Source: Current Opinion in Gastroenterology - Category: Gastroenterology Tags: STOMACH AND DUODENUM: Edited by Tilak U. Shah Source Type: research

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Source: Journal of Ultrasound - Category: Radiology Source Type: research
This study aimed to investigate the altered ultrasonographic activity of abdominal muscles during breathing in males with and without nonspecific chronic low back pain (NSCLBP).DesignCross-sectional study.MethodsTwenty males with NSCLBP and 20 males without NSCLBP were recruited. Muscle thickness change was measured by ultrasonography during breathing in the end-inspiration and end-expiration phases for the transverse abdominis (TrA), internal oblique (IO), external oblique (EO), and rectus abdominis (RA) muscles. The data were normalized to the end-inspiration thickness. An independentt test was run to analyze the data at...
Source: Journal of Ultrasound - Category: Radiology Source Type: research
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Source: Journal of Ultrasound - Category: Radiology Source Type: research
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Source: The American Journal of Dermatopathology - Category: Pathology Tags: Extraordinary Case Report Source Type: research
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Source: Journal of Neurology - Category: Neurology Source Type: research
Pain is a common nonmotor symptom in patients with Parkinson disease (PD) but the correct diagnosis of the respective cause remains difficult because suitable tools are lacking, so far. We developed a framework to differentiate PD- from non-PD-related pain and classify PD-related pain into 3 groups based on validated mechanistic pain descriptors (nociceptive, neuropathic, or nociplastic), which encompass all the previously described PD pain types. Severity of PD-related pain syndromes was scored by ratings of intensity, frequency, and interference with daily living activities. The PD-Pain Classification System (PD-PCS) was...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
Watching TV throughout the week, you can be inundated by pharmacological commercials. One for a recently identified condition, Tardive Dyskinesia, may pique your attention. What is TD?  Shaking and tremors that are the result of decades long use of antipsychotic medications. Such medications prescribed since the 1960s can cause TD, a condition potentially treatable by taking a supplemental medication.  Few, if any, longitudinal studies of the adverse effects of these drugs exist. It is only recently that we have begun to record the unforeseen effects of continued use of many psychiatric medications — from t...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Antipsychotic Medications Antipsychotics Pharmaceutical Advertising psychopharmaceuticals tardive dyskinesia Source Type: blogs
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Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Brain and Behavior Disorders General Inside Schizophrenia Mental Health and Wellness Active psychosis Delusions Delusions Hallucinations Living with Schizoprenia Mental Disorder Mental Illness Psychology psychotic Psychotic Break Source Type: blogs
 Rachel Star Withers is a speaker, YouTuber, and lives with schizophrenia. She is also a professional stunt woman and tends to describe herself as a “schizo stunt girl.”     In this episode, Rachel tells us a little of her history with the disease and details how she first started in mental illness activism.  Originally meant to just help other people with schizophrenia know that they were not alone, her YouTube channel, RachelStarLive, has become the longest existing chronicle of a personal experience with schizophrenia.  Listen Now! SUBSCRIBE &REVIEW   Guest information for &...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Peer Support Podcast Schizophrenia The Psych Central Show Source Type: blogs
Conclusions The treatment used for PD, particularly DA, is associated with the development of ICDs and related behaviors. Susceptibility to these disorders depends on the associated risk factors. ICDs can have serious personal, family, psychosocial, financial, and medical consequences. However, in contrast, artistic activities have been described in patients with PD while undergoing treatment with DA. These patients are compulsive but report a positive influence on quality of life. These findings highlight the need for a very critical approach at the moment of Dopaminergic Replacement therapy choice. Author Contributio...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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