Nicotine Exacerbates TAAD Formation Induced by Smooth Muscle-Specific Deletion of the TGF- < em > β < /em > Receptor 2

In conclusion, modeling nicotine exacerbation of TAAD formation requires optimization of chemical form, route of delivery, and dosage of the drug as well as the pathologic complexity of TAADs. Under the optimized conditions of the present study, chronic inflammation and adventitial mal-remodeling serve as critical pathways through which NFB exacerbates TAAD formation.PMID:34646889 | PMC:PMC8505064 | DOI:10.1155/2021/6880036

Source: Journal of Immunology Research - October 14, 2021 Category: Allergy & Immunology Authors: Changzoon Chun Xiaoyan Qi Fen Wang Kyle B Madrid Lennon A Saldarriaga Max R Fisch Mark L Brantly Gilbert R Upchurch Zhihua Jiang Source Type: research