Molecules, Vol. 26, Pages 6251: Phytochemical Profile, Free Radical Scavenging and Anti-Inflammatory Properties of Acalypha Indica Root Extract: Evidence from In Vitro and In Vivo Studies
Molecules, Vol. 26, Pages 6251: Phytochemical Profile, Free Radical Scavenging and Anti-Inflammatory Properties of Acalypha Indica Root Extract: Evidence from In Vitro and In Vivo Studies
Molecules doi: 10.3390/molecules26206251
Authors:
Ravi Sahukari
Jyothi Punabaka
Shanmugam Bhasha
Venkata Subbaiah Ganjikunta
Shanmugam Kondeti Ramudu
Sathyavelu Reddy Kesireddy
Weibing Ye
Mallikarjuna Korivi
In our in vitro and in vivo studies, we used Acalypha indica root methanolic extract (AIRME), and investigated their free radical scavenging/antioxidant and anti-inflammatory properties. Primarily, phytochemical analysis showed rich content of phenols (70.92 mg of gallic acid/g) and flavonoids (16.01 mg of rutin/g) in AIRME. We then performed HR-LC-MS and GC-MS analyses, and identified 101 and 14 phytochemical compounds, respectively. Among them, ramipril glucuronide (1.563%), antimycin A (1.324%), swietenine (1.134%), quinone (1.152%), oxprenolol (1.118%), choline (0.847%), bumetanide (0.847%) and fenofibrate (0.711%) are the predominant phytomolecules. Evidence from in vitro studies revealed that AIRME scavenges DPPH and hydroxyl radicals in a concentration dependent manner (10–50 μg/mL). Similarly, hydrogen peroxide and lipid peroxidation were also remarkably inhibited by AIRME as concentration increases (20–100 μg/mL). In vitro antioxidant activity of AIRME was comparable to ascorbic acid treatment. For in vivo studies, carrageenan (1%, sub-plantar) was in...
Source: Molecules - Category: Chemistry Authors: Ravi Sahukari Jyothi Punabaka Shanmugam Bhasha Venkata Subbaiah Ganjikunta Shanmugam Kondeti Ramudu Sathyavelu Reddy Kesireddy Weibing Ye Mallikarjuna Korivi Tags: Article Source Type: research
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