Acute hemodynamic and renal effects of glucagon-like peptide 1 analog and dipeptidyl peptidase-4 inhibitor in rats

Conclusion:
The results of the present study demonstrated that a GLP-1 analog and a DPP4 inhibitor may have beneficial effects on renal sodium and water handling. Additionally, the DPP4 inhibitor, MK-0626, favorably affects renal hemodynamics by increasing RBF. However, exceedingly high levels of GLP-1 receptor agonists may adversely affect the cardiovascular system in acute setting, as demonstrated by an acute increase in HR.

Source: Cardiovascular Diabetology - March 7, 2015 Category: Cardiology Authors: Xiaoyan ZhouChin-hu HuangJulie LaoAlessandro PocaiGail ForrestOlga PriceSophie RoyDavid KelleyKathleen SullivanMichael Forrest Source Type: research