Blockade of kappa opioid receptors reduces mechanical hyperalgesia and anxiety-like behavior in a rat model of trigeminal neuropathic pain

In conclusion, the kappa opioid system may represent a promising target to be explored for the control of trigeminal pain and associated anxiety. However, further studies are necessary to better elucidate its functioning and modulatory role in chronic trigeminal pain states.PMID:34592375 | DOI:10.1016/j.bbr.2021.113595

Source: Behavioural Brain Research - September 30, 2021 Category: Neurology Authors: Joelle de Melo Turnes Erika Ivanna Araya Amanda Ribeiro Barroso Darciane Favero Baggio Laura de Oliveira Koren Jana ína Menezes Zanoveli Juliana Geremias Chichorro Source Type: research