Oncofertility: a Review

AbstractPurpose of ReviewThe purpose of this review is to describe the latest methods of fertility preservation for female cancer patients, as well as the associated psychological benefits, pregnancy outcomes, and oncological outcomes of these techniques.Recent FindingsUsing random-start controlled ovarian stimulation for embryo and oocyte cryopreservation provides adequate oocyte yield and minimizes delay to starting cancer treatment. Protocols including estrogen-lowering medications should be used in women with hormone-sensitive cancers. Newer methods including ovarian tissue cryopreservation and ovarian transposition have promising pregnancy outcomes. Ovarian suppression helps prevent premature ovarian failure in young women with breast cancer and women who require rapid start systemic cancer treatment. Fertility-sparing surgery is safe in women with early-stage cervical and ovarian cancer. Providing counseling regarding fertility preservation yields significant psychological benefits for patients.SummaryImproved cancer survival and delayed childbearing have resulted in a greater need for fertility preservation for female cancer patients. The most commonly used fertility preservation strategy is controlled ovarian stimulation (COS). A number of new studies provide data on ways to maximize COS such as through use of random-start protocols and the addition of medications that lower estrogen levels. Recent research also suggests that newer methods including ovarian tissue cry...
Source: Current Obstetrics and Gynecology Reports - Category: OBGYN Source Type: research