Association of plasma trimethylamine N-oxide levels with atherosclerotic cardiovascular disease and factors of the metabolic syndrome

The association of plasma trimethylamine N-oxide (TMAO) with atherosclerotic cardiovascular disease (ASCVD), diabetes mellitus (DM) and its determinants, as well as the role of TMAO as a predictor for short and long-term mortality, is still under discussion. We investigated associations between four plasma metabolites of the TMAO pathway and different clinical manifestations of atherosclerosis, diabetes determinants, and risk of short and long-term mortality in patients with stable ASCVD, acute myocardial infarction (AMI), cardiogenic shock (CS), and DM in three independent cohorts.

Source: Atherosclerosis - September 22, 2021 Category: Cardiology Authors: Clemens Ringel, Julia Dittrich, Alexander Gaudl, Paul Schellong, Carl Friedrich Beuchel, Ronny Baber, Frank Beutner, Andrej Teren, Christoph Engel, Kerstin Wirkner, Holger Thiele, Petra B üttner, Markus Löffler, Markus Scholz, Joachim Thiery, Uta Ceglar Source Type: research