The newborn metabolome: associations with gestational diabetes, sex, gestation, birth mode, and birth weight

CONCLUSIONS: Neonatal factors, particularly delivery mode, were associated with many cord blood metabolite differences, including those implicated in later risk of cardiometabolic disease. Associations between GDM and higher offspring ketone levels at birth are consistent with maternal ketosis in diabetic pregnancies. Further work is needed to determine whether these neonatal metabolome differences associate with later health outcomes.IMPACT: Variations in blood metabolomic profile have been linked to health status in adults and children, but corresponding data in neonates are scarce. We report evidence that pregnancy complications, mode of delivery, and offspring characteristics, including sex, are independently associated with a range of circulating metabolites at birth, including ketone bodies, amino acids, cholesterols, and inflammatory markers. Independent of birth weight, exposure to gestational diabetes is associated with higher cord blood ketone bodies and citrate. These findings suggest that pregnancy complications, mode of delivery, gestational age, and measures of growth influence metabolic pathways prior to birth, potentially impacting later health and development.PMID:34526650 | DOI:10.1038/s41390-021-01672-7
Source: Pediatric Research - Category: Pediatrics Authors: Source Type: research

Related Links:

This study aimed to evaluate these associations and the neonatal health of the newborns born from pregnant women with and without GBP. A retrospective 1:5 case-control study matching exact maternal age and gravidity between pregnant women with and without GBP in Songklanagarind Hospital from 2006 to 2016 was conducted. The associations between GBP and PE, EC, GHT, and GDM, as well as comparison of the newborns’ health indices were analyzed by bivariate analysis (p < 0.05). Eight GBP cases out of 8,756 pregnant women were recruited. Six GBP cases were first or second gravid. GBP occurred during the third trimes...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
by Chen Huang, Jiong Li, Guoyou Qin, Zeyan Liew, Jing Hu, Krisztina D. L ászló, Fangbiao Tao, Carsten Obel, Jørn Olsen, Yongfu Yu BackgroundThe prevalence of cardiovascular disease (CVD) has been increasing in children, adolescents, and young adults in recent decades. Exposure to adverse intrauterine environment in fetal life may contribute to the elevated risk of early-onset CVD. Many studies have shown that maternal hypertensive disorders of pregnancy (HDP) are associated with increased risks of congenital heart disease, high blood pressure, increased BMI, and systemic vascular dysfunction in offspri...
Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research
Clin Mol Hepatol. 2021 Sep 17. doi: 10.3350/cmh.2021.0205. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: Maternal and fetal outcomes in pregnant patients with NAFLD have been largely unexplored. To determine the level of evidence associated with both maternal and fetal outcomes in pregnant women with NAFLD.METHOD: We conducted a comprehensive literature search. The studies included pregnant patients with a previous, current or subsequent diagnosis of NAFLD. We used a random-effects model using odds ratios (OR) with 95% confidence intervals (CI).RESULTS: Twenty two studies, with 13641 female NAFLD patients were reviewe...
Source: Clinical and molecular hepatology - Category: Gastroenterology Authors: Source Type: research
Clin Mol Hepatol. 2021 Sep 17. doi: 10.3350/cmh.2021.0205. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: Maternal and fetal outcomes in pregnant patients with NAFLD have been largely unexplored. To determine the level of evidence associated with both maternal and fetal outcomes in pregnant women with NAFLD.METHOD: We conducted a comprehensive literature search. The studies included pregnant patients with a previous, current or subsequent diagnosis of NAFLD. We used a random-effects model using odds ratios (OR) with 95% confidence intervals (CI).RESULTS: Twenty two studies, with 13641 female NAFLD patients were reviewe...
Source: Clinical and molecular hepatology - Category: Gastroenterology Authors: Source Type: research
Clin Mol Hepatol. 2021 Sep 17. doi: 10.3350/cmh.2021.0205. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: Maternal and fetal outcomes in pregnant patients with NAFLD have been largely unexplored. To determine the level of evidence associated with both maternal and fetal outcomes in pregnant women with NAFLD.METHOD: We conducted a comprehensive literature search. The studies included pregnant patients with a previous, current or subsequent diagnosis of NAFLD. We used a random-effects model using odds ratios (OR) with 95% confidence intervals (CI).RESULTS: Twenty two studies, with 13641 female NAFLD patients were reviewe...
Source: Clinical and molecular hepatology - Category: Gastroenterology Authors: Source Type: research
AbstractGestational diabetes mellitus (GDM) is the most common form of dysglycaemia during pregnancy. GDM is defined as hyperglycemia diagnosed for the first time during pregnancy, most commonly during the second or third trimester. GDM can be harmful to both the mother and the offspring. Complications to fetuses include excessive birthweight and preterm birth, while women with GDM are more susceptible to gestational hypertension, pre-eclampsia, and postpartum abnormal glucose intolerance (pAGT).
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: UPDATE Source Type: research
CONCLUSION: Physical activity interventions must be performed for a minimum of three times per week, at least at moderate intensity, and must be based on aerobic, resistance and strength exercises. Both for the prevention and treatment of this disease, the physical activity must be performed for a minimum of three times per week, at least at moderate intensity, and must be based on aerobic, resistance and strength exercises.PMID:34420508 | DOI:10.2174/1573399817666210820110941
Source: Current Diabetes Reviews - Category: Endocrinology Authors: Source Type: research
tani Hussain Alqhtani The increasing frequency of cesarean section (CS) is a major public health issue, and it is on the rise in Pakistan. A cross-sectional study approach was used to assess the frequency of CS and its contributing factors, along with the assessment of knowledge in mothers who had undergone CS in one of the under-developed regions of Pakistan. Data collection was done by using a self-developed study questionnaire. The statistical package for social sciences (SPSS) was utilized for the statistical analysis. During the study period, a total of 173 (69.7%) women have given births by CS; among those, 104...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
AbstractBackground and AimsPrevious studies have been inconsistent in reporting the risk of pregnancy-related complications in women with IBD. We aimed to investigate the differences in frequencies of pregnancy-related complications requiring hospitalization in women with IBD compared to women without IBD.MethodsWe performed a population-based, cross-sectional study using the 2014 USA National Inpatient Sample. Frequencies of ICD-9 codes for pregnancy-related complications in women aged 18 –35 years with IBD were compared to women with no IBD controlling for confounders predisposing to pregnancy complications. A...
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
AbstractStudy questionDoes primary hyperaldosteronism(PA) confer an independent risk for adverse pregnancy or neonatal outcomes, based on analysis of the Healthcare-Cost and Utilization Project-Nationwide Inpatient Sample(HCUP-NIS) database?Summary answerAfter controlling for all significant confounders, women with PA are at increased risk for gestational hypertension, eclampsia, and operative vaginal delivery, but unexpectedly not preeclampsiaWhat is known alreadyPA is extremely rare in pregnancy, and our current knowledge regarding PA during pregnancy is derived only from case reports and series. No pregnancy control stu...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
More News: Cardiology | Child Development | Children | Diabetes | Endocrinology | Heart | Pediatrics | Perinatology & Neonatology | Pre-eclampsia | Pregnancy | Smokers | Study