Microstructural Characterization of Resistance Artery Remodelling in Diabetes Mellitus

Conclusions: Our results suggest diabetic microvascular remodelling is likely to be stress-driven, comprising at least 2 stages: (1) Laying down of adventitial bracing fibres that limit outward distension, and (2) Deposition of additional collagen in the media, likely due to the significantly altered mechanical environment. This work represents a step towards elucidating the local stress environment of cells, which is crucial to build accurate models of mechanotransduction in disease.J Vasc Res
Source: Journal of Vascular Research - Category: Research Source Type: research