C-reactive protein and risk of Alzheimer's disease

This study indicates that genetically predicted elevated CRP levels may be a causal risk factor for AD.PMID:34538509 | DOI:10.1016/j.neurobiolaging.2021.08.010
Source: Neurobiology of Aging - Category: Geriatrics Authors: Source Type: research

Related Links:

New J. Chem., 2021, Advance Article DOI: 10.1039/D1NJ04453B, PaperIshrat Jahan, Shahid M. Nayeem Among the neurodegenerative diseases, one of the most common dementia is Alzheimer's disease (AD). To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Certain blood pressure –lowering agents, especially diuretics, may reduce Alzheimer's pathology and other brain disease processes, new research suggests.Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news
A major gap exists in the present spectrum of efforts to develop the means to treat aging, rejuvenate the old, and turn back age-related conditions. An the one hand, a small number of promising potential therapies to treat the mechanisms of aging can at present be applied by physicians off-label, or otherwise without the need for a great deal of interaction with the FDA. On the other hand, there are a good hundred or more clinical indications, specific age-related conditions recognized by regulatory authorities, that might be improved by these therapies. Several hundred small, informal trials could be run, starting now, gi...
Source: Fight Aging! - Category: Research Authors: Tags: Activism, Advocacy and Education Source Type: blogs
AbstractTrazodone is a widely used antidepressant that is also useful in the control of agitation and insomnia in Alzheimer's disease. This drug is now recognized as having a new mechanism of action, an effect on the unfolded protein response (UPR) pathway, restoring protein translation and slowing neurodegenerative progression in mice. This mechanism may have a role in dementia-modifying treatment.  To explore the effects of trazodone on human cognition and to search for clinical evidence of its putative benefits in human neurodegenerative diseases, a systematic review was conducted for studies that evaluated the eff...
Source: European Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionsBy using PIM-Check in geriatric settings, some PIP will not be detected. It is considered as a limitation for this tool in this frail population but brings a certain complementarity in other areas of therapy not covered by STOPP/START.
Source: European Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Source Type: research
Baseline MRI exam findings in patients with early-onset Alzheimer's diseas...Read more on AuntMinnie.comRelated Reading: Brain MRI shows link between atrial fibrillation and cognitive decline MRI shows link between white-matter hyperintensities and brain health Tau PET bests amyloid PET, MRI in Alzheimer's prognostic study MRI shows how anxiety speeds Alzheimer's progression MRI, PET strengthen iron, tau link to Alzheimer's
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Contributors : Hemraj B Dodiya ; Sangram S Sisodia ; Priyam PatelSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRecent evidence suggests an important role of the gut microbiome in early life on immune cell entraining. Using two independent transgenic (Tg) lines of Alzheimer ’s disease, we have demonstrated that life-long antibiotic (ABX)-perturbation of the gut microbiome is associated with reduced amyloid beta (Ab) plaque pathology and microglial phenotypes in male mice. Furthermore, fecal microbiota transfer (FMT) from age-matched APPPS1-21 Tg mice into long-term A BX-treated...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Source: Frontiers in Neurology - Category: Neurology Source Type: research
This Viewpoint uses the accelerated approval of aducanumab to treat Alzheimer disease to discuss what role patient desperation should play in the FDA ’s decision-making.
Source: JAMA Internal Medicine - Category: Internal Medicine Source Type: research
This study confirmed that the PSI could be a quantitative index of vascular aging and has potential for use in inferring arterial stiffness with an advantage over the rAIx. A Profile of Michael Greve and the Segment of the Longevity Industry that He Supports https://www.fightaging.org/archives/2021/10/a-profile-of-michael-greve-and-the-segment-of-the-longevity-industry-that-he-supports/ Would that the popular media produced more popular science articles about the longevity industry like this one. It is not just a profile of someone trying to make a difference in the world by advancing the state of medici...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
More News: Alzheimer's | Brain | Genetics | Geriatrics | Men | Neurology | Study