A Research Domain Criteria Approach to Gambling Disorder and Behavioral Addictions: Decision-Making, Response Inhibition, and the Role of Cannabidiol

Gambling Disorder (GD) has been recently re-classified in the DSM-5 under the “substance-related and addictive disorders,” in light of its genetic, endophenotypic, and phenotypic resemblances to substance dependence. Diminished control is a core defining concept of psychoactive substance dependence or addiction and has given rise to the concept of “behavioral” addictions, which are syndromes analogous to substance addiction, but with a behavioral focus other than ingestion of a psychoactive substance. The main symptom clusters are represented by loss of control, craving/withdrawal, and neglect of other areas of life, whereas in a Research Domain Criteria (RDoC) perspective, GD patients exhibit deficits in the domain of “Positive valence systems,” particularly in the “Approach motivation” and “Reward learning” constructs, as well as in the “Cognitive systems,” primarily in the “Cognitive control” construct. In the Addictions Neuroclinical Assessment (ANA), three relevant domains for addictions emerge: “Incentive salience,” “Negative Emotionality,” and “Executive Function.” The endocannabinoid system (ECS) may largely modulate these circuits, presenting a promising pharmaceutical avenue for treating addictions. Up to now, research on cannabidiol has shown some efficacy in Attention Deficit/Hyperactivity Disorder (ADHD), whereas in behavioral addictions its rol...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research

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Mem Cognit. 2021 Oct 14. doi: 10.3758/s13421-021-01246-2. Online ahead of print.ABSTRACTThe ability to detect an error in performance is critical to ongoing and future goal-directed behaviour. Diminished awareness of errors has been associated with a loss of insight and poor functional recovery in several clinical disorders (e.g., attention-deficit/hyperactivity disorder, addiction, schizophrenia). Despite the clear imperative to understand and remediate such deficits, error awareness and its instantiation in corrective behaviour remains to be fully elucidated. The present study investigated the relationship between error ...
Source: Memory and Cognition - Category: Neuroscience Authors: Source Type: research
Source: International Journal of Mental Health and Addiction - Category: Addiction Source Type: research
CONCLUSIONS AND DISCUSSION: ADHD in adults with tramadol use is common and is associated with early-onset, high dose, and long duration of tramadol use.SCIENTIFIC SIGNIFICANCE: This is the first study to investigate the co-occurrence of ADHD and tramadol misuse among adults.PMID:34608707 | DOI:10.1111/ajad.13231
Source: American Journal on Addictions - Category: Addiction Authors: Source Type: research
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