The DosR Regulon Modulates Adaptive Immunity and is Essential for M. tuberculosis Persistence.

Conclusions: Delayed adaptive responses, a hallmark of Mtb infection, not only lead to persistence but also interfere with the development of effective anti-TB vaccines. The DosR regulon therefore modulates both the magnitude and the timing of adaptive immune responses in response to hypoxia in-vivo, resulting in persistent infection. Hence, DosR regulates key aspects of the Mtb life cycle and in limiting lung pathology. PMID: 25730547 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/25730547?dopt=Abstract

Source: American Journal of Respiratory and Critical Care Medicine - March 2, 2015 Category: Respiratory Medicine Authors: Mehra S, Foreman TW, Didier PJ, Ahsan MH, Hudock TA, Kissee R, Golden NA, Gautam US, Johnson AM, Alvarez X, Russell-Lodrigue KE, Doyle LA, Roy CJ, Blanchard JL, Khader SA, Lackner AA, Sherman DR, Kaushal D Tags: Am J Respir Crit Care Med Source Type: research