DNA hypermethylation of PTPN22 gene promoter in children and adolescents with Hashimoto thyroiditis

ConclusionsThis study demonstrates for the first time that a relationship between autoimmune thyroiditis andPTPN22 gene promoter DNA methylation state is present, thus proposing another possible etiological association between thyroiditis and abnormalities ofPTPN22 function. Further expression studies are required to confirm these findings.
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research