Molecular epidemiology of Burkholderia mallei isolates from India (2015-2016): New SNP markers for strain tracing

In this study, 10 B. mallei strains isolated from four states in India during 2015-2016 were whole genome sequenced; SNP analysis further confirmed their position in the L2B2sB2 branch. To better track the strains, four new markers targeting Indian or Pakistani strains, and specifically targeting sub-groups within the Indian strains, were identified. The new SNP markers were tested and validated on the 10 Indian isolates included in this study as well as on 6 contemporary B. mallei Pakistani strains. These rapid and discriminating typing tools will contribute to the epidemiological monitoring of B. mallei infections, particularly in South Asia and the Middle East, endemic regions of the disease.PMID:34478841 | DOI:10.1016/j.meegid.2021.105059

Source: Infection, Genetics and Evolution - September 3, 2021 Category: Genetics & Stem Cells Authors: H Singha F Vorimore Sheetal Saini T Deshayes M Saqib B N Tripathi K Laroucau Source Type: research