Use of oral estradiol plus vaginal progesterone in healthy postmenopausal women

Data strongly suggest that estrogen replacement therapy is associated with beneficial effects on cardiovascular disease (CVD) when initiated within 10 years of the menopause [1, 2]. Growing evidence for the timing hypothesis supports the effects of postmenopausal estrogen therapy on atherosclerosis and CVD depending on the timing of the initiation of hormone therapy (HT) relative to menopause, age, or both [3-5]. Estrogen hormone replacement most effectively slows atherosclerosis when underlying vascular tissue is healthy and maintains up-regulated estrogen receptors [5-8].

Source: Maturitas - September 5, 2021 Category: Primary Care Authors: Intira Sriprasert, Melissa Mert, Wendy J. Mack, Howard N. Hodis, Donna Shoupe Source Type: research